(c) 2011 Wiley Periodicals, Inc. Environ Toxicol, 2011.”
“Tributyltin (TBT), a proven endocrine-disrupting chemical, is well known to induce imposex in female gastropods. Herein we demonstrate the effects of low doses of tributyltin chloride (TBTCl) on the female CBL0137 offspring of KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 mu g TBTCl/kg body
weight/day from day 6 of pregnancy through the period of lactation. TBTCl dramatically advanced the age of onset of vaginal opening (VO) and first vaginal estrus, and reduced body weights at VO and first estrus. Furthermore, perinatal treatment with TBTCl significantly reduced the number of days between VO and first estrus. In addition, female offspring from dams exposed to 10 and 100 mu g kg-1 TBTCl exhibited altered patterns of estrous cyclicity in adulthood. In conclusion, perinatal exposure to low doses TBTCl result in early puberty and impaired estrous cyclicity in female mice, which suggest that TBTCl might act as an estrogen agonist or/and a disruptor on hypothalamicpituitary function in the present study. (c) 2012 Wiley Periodicals, Inc. Environ Toxicol, 2012.”
“Environmental protection of Antarctica is a fundamental principle
of the Antarctic Treaty. Impact assessment and significance evaluation are due for every human activity on the remote continent. While chemical and biological contaminations are widely studied, very little is known about the electromagnetic pollution Selleck JNK inhibitor levels. In this frame, we have evaluated the significance of the impact of Mario Zucchelli Antarctic Station (Northern Victoria Land) on the local geomagnetic field. We have
flown a high resolution aeromagnetic survey in drape mode at 320 m over the Station, covering an area of 2 km(2). The regional and the local field have been separated by a third order polynomial fitting. After the identification of the anthropic magnetic anomaly due to the Station, we have Buparlisib estimated the magnetic field at the ground level by downward continuation with an original inversion scheme regularized by a minimum gradient support functional to avoid high frequency noise effects. The resulting anthropic static magnetic field at ground extends up to 650 m far from the Station and reaches a maximum peak to peak value of about 2800 nT. This anthropic magnetic anomaly may interact with biological systems, raising the necessity to evaluate the significance of the static magnetic impact of human installations in order to protect the electromagnetic environment and the biota of Antarctica. (C) 2012 Elsevier Ltd. All rights reserved.