The subjects were randomly divided into four groups: 2 normoglycemic obese groups (active; placebo) and two type 2 diabetic obese groups (active; placebo). Capsules containing the active (400 mg DG) or placebo PCI-34051 formulation were administered 30-60 min before lunch and dinner throughout the study period. A total of 7 anthropometric and hemodynamic as well as 7 biochemical measurements were taken at the beginning of the study and after 4 and 8 weeks of treatment. All diabetic patients maintained their prior lifestyle intervention and dietary
control for the duration of the study. Compared to the two placebo groups, the two active groups showed statistically significant differences on all 14 variables between Weeks 0 and 8. These included body weight, BMI, waist and hip circumference, body fat, blood pressure, blood cholesterol, triglycerides, glucose, and glycosylated hemoglobulin. The results confirm the hypothesis that DC appears to
reduce cardiovascular disease risk factors in obese normoglycemic Z-VAD-FMK and obese type 2 diabetic human subjects. (C) 2010 Elsevier Ltd. All rights reserved.”
“To compare the results of patients on whom staging was applied by robotic-assisted laparoscopic surgery and laparotomy for endometrial cancer.
The study included 10 patients who had undergone robotic-assisted endometrial staging (group 1) and 12 patients staged by open surgery (group 2). Demographical characteristics and operative outcomes of all patients were compared. Body mass index, age, previous abdominal surgeries, histopathologic characteristics, performed operative procedure, operation time, complications, hospitalization duration, estimated blood loss and number of resected lymph nodes were recorded for all patients.
Mean age of the patients in the robotic surgery group was 55.7 years (37-66) and in the laparotomy group 56.4 years (47-75). Body mass index was calculated as 32.7 kg/m(2) (24.5-40.3) in group 1 and 30.3 kg/m(2) (25.9-35.8) in HSP990 cost group
2. Total duration of operation was 234.6 min (137-300) and 168.5 min (102-232) in group 1 and 2, respectively. Mean duration of hospitalization in group 1 was 2.8 days (2-5) and in group 2 was 8.8 days (6-13). Estimates of blood loss were 95 ml (20-210 ml) in the robotic surgery group and 255 ml (80-420) in the other group. The mean number of resected lymph nodes was 42 (13-86) and 46.5 (26-107) in the robotic-assisted surgery group and laparotomy group, respectively. None of the cases in the robotic-assisted endometrial staging group required transition to laparotomy.
Robotic surgery may be preferred over laparotomy with respect to the advantages observed in the duration of hospitalization, estimated amount of blood loss and complications. There was no significant difference between the two methods in terms of number of resected lymph nodes.