Prevention efforts in France should focus on reducing not only food-borne but also person-to-person transmission.”
The survival of patients returning to hemodialysis (HD) following kidney transplant failure is unfavorable. However, the factors responsible
for this poor outcome are largely unknown; chronic inflammation due to failed allograft and malnutrition may GM6001 clinical trial contribute to morbidity and mortality. We aimed to compare the nutritional status and its relation with inflammation in patients on HD with and without previous kidney transplantation.
Forty-three patients with failed renal allografts (27 males; mean age 36 +/- 9 yr) and 40 never transplanted HD patients (24 males; mean age 39 +/- 9 yr) were included GW4869 in the study. Body weight, triceps (TSF), biceps (BSF), subscapular (SSSF), and suprailiac skinfold thicknesses (SISF); mid-arm, mid-arm muscle, hip and waist circumferences; as well as body mass indices (BMIs) were determined as anthropometric
parameters. Moreover, biochemical markers of nutritional status, including serum cholesterol and albumin as well as high-sensitive C-reactive protein (hs-CRP), as a marker of inflammation, were measured. Associations among these variables were analyzed.
There were no significant differences considering age, gender or duration of renal replacement therapy between the two groups. The TSF (p < 0.0001), BSF (p = 0.005), SSSF (p = 0.001), SISF (p < 0.0001) skinfold thicknesses; mid-arm (p = 0.003) and mid-arm muscle circumferences (p = 0.037) and BMIs (p = 0.001) of the patients with failed renal allografts were significantly lower than those CDK inhibitor of the never transplanted HD patients. Waist circumference was significantly lower as well (p = 0.028). Patients with failed transplants were characterized by lower serum albumin (p < 0.0001) and higher hs-CRP levels (p = 0.001) as compared with never transplanted HD patients.
This study confirms the concept that
retained failed allografts may induce chronic inflammation in chronic HD patients which may result in a worse nutritional status.”
“Pain intensity may be high in the postoperative period after spinal vertebral surgery. The aim of the study was to compare the effectiveness and cost of patient controlled analgesia (PCA) with tramadol versus low dose tramadol-paracetamol on postoperative pain. A total of 60 patients were randomly divided into two groups. One group received 1.5 mg/kg tramadol (Group T) while the other group received 0.75 mg/kg tramadol plus 1 g of paracetamol (Group P) intravenously via a PCA device immediately after surgery and the patients were transferred to a recovery room, Tramadol was continuously infused at a rate of 0.