Piperine theory that pregnancy protects against hormone receptor-positive cancers . Other work has shown that multiparous women have an even lower risk of developing breast cancer than uniparous women . The reduction of breast cancer risk after full-term pregnancy may be related to a MU response. Vaccines that elicit a MUC immune response may be useful in mimicking a multiparous woman as a preventive strategy. In conclusi we demonstrated that: ) T polarization of L-BL 5-induced immune response is unaffected by concurrent administration of tamoxifen or letrozo and ) L-BL 5 vaccine whenbined with letrozole has additive antitumor activity. Both observations support the clinical testing of abination therapy of L-BL 5 with letrozole for the treatment and prevention of breast cancer. ACKNOWLEDGEMENTS:

We would like thank Kate Wasso and Beverly Packard for their valuable technical  Salidroside 10338-51-9 assistance. We would like to extend a special thanks to Dr. Oscar Kashala for his expert opinions and feedback. FINANCIAL SUPPORT: This work was supported by a grant from Merck-KG Darmsta Germany. 1 Downloaded from clincancerres.aacrjournals on March 9, Copyright American Association for Cancer Research Author Manuscript Published OnlineFirst on March 0.  Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 2 Downloaded from clincancerres.aacrjournals on March 9, Copyright American Association for Cancer Research Author Manuscript Published OnlineFirst on March 0.  Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. References . Lacey J Devesa Brinton LA. Recent trends in breast cancer buy MK-8669 incidence and mortality. Environ Mol Mutagen 2 Senn Morant R.

Chemoprevention of breast and prostate cancers: where do we stand Ann Oncol 9 Suppl :vi Al Masri A, Gendler SJ. Mu affects c-Src signaling in PyV MT-induced mammary tumorigenesis. Oncogene. Takahashi T, Makiguchi Y, Hinoda Y, Kakiuchi H, Nakagawa N, Imai K, Expression of MU on myeloma cells and induction of HLA-unrestricted CTL against MU from a multiple myeloma patient. Journal of Immunology Choi C, Witzens M, Bucur M, Feuerer M, Sommerfeldt N, Trojan A, Enrichment of functional C memory T cells specific for MU in bone marrow of patients with multiple myeloma. Blood Lakshminarayanan V, Thompson P, Wolfert Buskas T, Bradley Pathangey Immune recognition of tumor Paeonol inhibitor associated mucin MU is achieved by a fully synthetic aberrantly glycosylated MU tripartite vaccineroc Natl Acad Sci U S A . Gaidzik N, Kaiser A, Kowalczyk D, Westerlind U, Gerlitzki B, Sinn Synthetic Antitumor Vaccines Containing MU Glycopeptides with Two Immunodominant Domains-Induction of a Strong Immune Response against Breast Tumor Tissues.

Angew Chem Int Ed Engl inkhasov J, Alvarez Rigano Piensook K, Larios D, Pabst M, Rbinant plant-expressed tumour-associated MU peptide is immunogenic and capable of breaking tolerance in MU .Tg micelant Biotechnol J 1. 3 Downloaded from hydrazines clincancerres.aacrjournals on March 9, Copyright American Association for Cancer Research Author Manuscript Published OnlineFirst on March 0.  Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited Wilkinson Day S.