Imatinib  baseline procedur eligible participants were randomly assign in a double-blind fashion and in a ratio according to aputer-generated allocation schedu to receive amlodipine 0 mg or matching placebo once daily for weeks. Each site was assigned allocation num-bers in blocks of to ensure balanced distribution of participants between sites and treatment groups. All study personn including the investigato study site personn participan monito and central laboratory personnel remained blinded to treatment allocation throughout the study. Safety was monitored using physical examinati including repeated measurement of vital sig and spontaneously reported adverse events. Edema Assessments On days , 5, 9, and 3, after overnight stays in the clin a Patient-Perceived Edema questionnaire was administer immediately followed by edema assessments.

Edema assessments were conducted in a prespecid order: segmental bioimpedan clinical Volume 4 Number D.A. Schoeller pitting assessme ankle circumferen and water  Oridonin displacement volumetry. No more than 0 minutes elapsed betweenpletion of the bioimpedance as-sessment and the initiation of a sitting period that preceded the volumetry assessment; the clinical pit-ting and ankle circumference assessments were-pleted within the water displacement volumetry sit-ting period. Day was deed as the day on which participants were randomized and received the st dose of study drug. Individuals responsible for as-sessing edema were blinded to BP measurements throughout the study. The investigators performing the clinical pitting assessments were blinded to other edema measuremen BP measuremen and re-sponses on the questionnaire.

Segmental Bioimpedance The bioimpedance multifrequency analyzer ImpediMed SF was  epigallocatechin 989-51-5 used to measure leg impedance over a range of frequencies . The procedure involved passing an extremely small alternat-ing electrical current through the body and measuring the impedance to the ow of this current. Resistance measurements obtained at lower frequencies corresponded to cur-rent traveling through the extracellular i while measurements obtained at higher frequencies approximated the total bioresis-tance of the intracellular id in parallel with ECF. In the context of amlodipine-induced ede a decrease in low-frequency resistance was expect without a change in the intracellularpartment resistance. Bioimpedance at 0 k the readout with the smallest intrasubject SD based on triplicate measurements at baseli was selected as the primary end point; the other readouts were analyzed as secondary end points. For a given reado the median of the baseline measurements for that readout was used as the baseline value  buy flumazenil for analyses of changes from baseline.

Immediately after thepletion of the last 5-min-ute walking/standing interv segmental  anatomy bioimped-ance measurements were initiated. Participants re-trode was placed on the knee at the lower edge of the patel and a current-introducing electrode was placed on the ventral surface of the thi cm directly above the upper edge of the detection electrode. Another de-tection electrode was placed on the ankle at the level of and between the medial and lateral malleo and a current-producing electrode was placed on the dorsal surface of the fo cm proximal to the metatarsal phalangeal joint.