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click here The authors declare that they have no competing interests. Authors’ contributions HC carried out the cell proliferation assay and drafted the manuscript. JXY participated in the design of the study and performed the statistical analysis. SHY carried out cell culture and plasmid construction. HD carried out transfection and RT-PCR. RWZ carried out measurements of transketolase activity. SZ conceived of the study, and participated in its design and coordination. All authors read and approved the final manuscript.”
“Introduction Cell cycle checkpoint functions regulate cell cycle progression and proliferation. Defects of cell cycle control are one among hallmarks of tumor development and may have relevance in tumor predisposition [1]. Cyclin-dependant kinase 4 (CDK4) is an important gene for cell cycle regulation, as it determines the number of cells entering the G1 phase cell cycle [2]. It is located on chromosome 12q14 and the protein encoded within this gene is a member of Ser/Thr protein kinase family.