This study aimed to examine the relationship between birth-season and relative age at school on the risk of delinquency.
Methods: We investigated the ratio of observed and expected births in winter/summer and that in the first/last months of the Japanese school year in 5008 young male Japanese delinquents.
Results: No significant difference was found between observed and expected numbers of births in winter/summer or those in the first/last months of the school year.
Conclusions: The present study did not provide evidence for any effect from season of birth or a relative age effect
within the school year on the risk of delinquency in Japanese male selleck compound teenagers. (c) 2007 Elsevier Inc. All rights reserved.”
“BACKGROUND: High-grade gliomas of the spinal cord are poorly understood tumors that are very commonly associated with bad outcomes. The transforming effects of platelet-derived growth factor (PDGF) on spinal cord Cilengitide cell line glial progenitor cells may play an important role in the development of these tumors.
OBJECTIVE: To investigate the possible tumor-initiating effects of PDGF overexpression in the spinal cord, we delivered a PDGF retrovirus directly into the substance of the spinal cord.
METHODS: The spinal cords of wild-type adult rats were surgically exposed and injected with 10(6) colony-forming
units of a green fluorescent protein-tagged, PDGF-expressing retrovirus. A control virus was injected to assess the cell types that become infected during retroviral Mannose-binding protein-associated serine protease delivery to the spinal cord.
RESULTS: It was observed that PDGF overexpression in the
spinal cord causes morbidity from high-grade intramedullary glioma formation between 27 and 49 days after PDGF retrovirus injection. Retroviral transduction was highly efficient with 100% of injected animals displaying the tumor phenotype. The tumors produced were highly proliferative, were locally invasive, and displayed the immunophenotype of virus-targeted glial progenitor cells (lig2+PDGFR+NG2+GFAP-).
CONCLUSION: PDGF is capable of driving glial progenitor cells within the adult spinal cord to form high-grade gliomas. Further investigation of PDGF signaling in the spinal cord is needed to better understand and treat these devastating tumors.”
“Fast synaptic current at most excitatory synapses in the brain is carried by AMPA and NMDA subtypes of ionotropic glutamate receptors (AMPARs and NMDARs). During development there is an increase in the ratio of AMPAR- to NMDAR-mediated current at these synapses. Recent studies indicate that NMDAR signaling early in development negatively regulates AMPAR expression and function at multiple levels, which likely accounts for the I small AMPAR current at developing synapses. This contrasts with the positive role of NMDAR signaling in recruiting AMPARs to synapses during long-term potentiation in the adult brain.