This exploratory study led to improvements in the program and recommendations for further research. A study on the effectiveness of the program is the next step.”
“Background
For AC220 solubility dmso the past two decades, a mathematical model of micturition was built step by step. Fundamental studies, presentations of the model and several applications to various male and female lower urinary tract dysfunctions have been published. We expect now that other teams will be interested in using it. In order to do so, a VBN pack (software in Linux and tutorial) is freely available.
Aims
The purpose of this review is to describe the model and to show its practical usefulness.
Materials and Methods
After a short
description of the basis of the model and of how to use it, some published applications were summed up. The main application of the VBN model is to obtain a coherent modelling for a given patient from a set of several recordings (free uroflows and pressure-flow study) obtained either during the same session or in follow up.
Results
This experience gradually led us to study what information could be extracted from a free uroflow. In addition, the model is valuable to quickly compute the effect of some additional condition; thus, it Selleckchem MGCD0103 can predict the effect
of an experimental artefact (urethral catheter, penile cuff).
Conclusion
Because the process of fitting model computations and real recordings is a powerful way to detect unexpected phenomena, the use of the VBN model provides a method to improve the knowledge of misunderstood dysfunctions of the lower urinary tract. Neurourol. Urodynam. 33:361-366, 2014.
(c) 2013 Wiley Periodicals, Inc.”
“Objectives: The objective of this study was to evaluate the clinical features, course, outcome, and prognostic indicators in lupus membranous nephritis (LMN) and to compare data of “”pure”" LMN vs “”mixed”" forms.
Methods: We retrospectively examined medical records and kidney biopsies of 103 patients with a diagnosis of LMN.
Results: Sixty-seven patients had “”pure”" LMN and 36 had “”mixed”" forms. Patients with mixed LMN had more frequent nephrotic syndrome (66.6 vs 44.7%, P = 0.05), low C3 (83.3 vs 62.6%, P = 0.05) and C4 (80.5 vs 52.2%, P = 0.005), anti-DNA positivity (86.0 vs PF-00299804 mw 62.6%, P = 0.03), and a tendency toward a lower creatinine clearance (93 +/- 29 vs 112 +/- 50 mL/min, P = 0.07). Moreover, mixed membranous nephritis had a higher activity and chronicity index (6.5 +/- 2.1 vs 1.4 +/- 2.03, P = 0.005 and 2.4 +/- 1.7 vs 1.4 +/- 1.8, P = 0.0001, respectively). Methylprednisolone pulses and immunosuppressive therapy were more often used in patients with mixed forms (86.1 vs 60.6%, P = 0.016 and 83.3 vs 57.5%, P = 0.008, respectively). After a mean follow-up of 156.5 +/- 104.5 months, there was no difference in the 2 subgroups concerning the number of patients achieving remission and patient/renal survival (94.5 vs 94.0% and 85.8 vs 86% at 10 years).