The dosage of 6 g daily represents a low dose level of IP6 + Inositol. Extrapolated from animal data, in the absence of a dose-determination study R788 mw in humans, the recommended prophylactic dosage of IP6 + Inositol is 1-2 g/day and a cancer therapeutic dosage is 8-12 g/day [4]. Even though our dosage was low, its efficacy to diminish the side effects of chemotherapy was significant. Recent phase I study of inositol for lung cancer chemoprevention showed that in a daily dose of 18 g p.o. for 3 months, inositol was safe and well tolerated [21]. Recently it was reported that
the combination of beta-(1,3)/(1,6) D-glucan and IP6 was well tolerated and had beneficial effect on hematopoesis in the treatment of patients with advanced malignancies receiving chemotherapy [22]. Although
the results of our pilot studies are encouraging, it is necessary to PARP inhibitor conduct further multicentric clinical testing on a larger number buy AR-13324 of patients for further evaluation of the impact that IP6 + Inositol on the quality of life of patients treated from breast cancer. Acknowledgements We thank Goran Mijaljica, MD for the assistance in the preparation of this manuscript. References 1. World Health Statistics 2008 Geneva, World Health Organization; 2008. 2. Garcia M, Jemal A, Ward EM, Center MM, Hao Y, Siegel RL, Thun MJ: Global Cancer Facts & Figures 2007. Atlanta, GA: American Cancer Society; 2007. 3. Vucenik I, Shamsuddin AM: Cancer inhibition by inositol hexaphosphate (IP 6 ) and inositol: from laboratory to clinic. J Nutr 2003, 133:3778S-3784S.PubMed 4. Vucenik I, Shamsuddin AM: Protection against cancer by dietary IP 6 and inositol. Nutr Cancer 2006, 55:109–125.PubMedCrossRef 5. Tantivejkul K, Vucenik I, Shamsuddin AM: Inositol hexaphosphate (IP 6 ) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions. Anticancer Res 3689, 23:3681–2003. 6. Shamsuddin AM, Vucenik I, Cole KE: IP 6 : a novel anti-cancer agent. Life Sci 1977, 61:343–554.CrossRef 7. Yang GY, Shamsuddin AM: IP
6 -induced growth inhibition and differentiation of HT-29 human colon cancer cells: involvement of intracellular inositol phosphates. Anticancer Res 2487, 15:2479–1995. Cell press 8. Shamsuddin AM, Yang G-Y, Vucenik I: Novel anti-cancer functions of IP 6 : growth inhibition and differentiation of human mammary cancer cell lines in vitro . Anticancer Res 3292, 16:3287–1996. 9. Vucenik I, Passanti A, Vitolo MI, Tantivejkul K, Eggleton P, Shamsuddin AM: Anti-angiogenic activity of inositol hexaphosphate (IP 6 ). Carcinogenesis 2123, 25:2115–2004.CrossRef 10. Vucenik I, Zhang ZS, Shamsuddin AM: IP 6 in treatment of liver cancer. II. Intra-tumoral injection of IP 6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res 4096, 18:4091–1998. 11. Lee HJ, Lee SA, Choi H: Dietary administration of inositol and/or inositol-6-phosphate prevents chemicaly-induced rat hepatocarcinogenesis.