The data analysis of values obtained from various batches for the angle of repose, disintegration time, percentage cumulative drug release at 30 min were subjected to multiple regression analysis using PCP Disso software. The response surfaces of the obtained results were also plotted. The equation fitted was Y=ß0+ß1X1+ß2X2+ß11X12+ß22X22+ß12X1X2Where, Y is the measured response; X is the

levels of factors; β is the coefficient computed from the responses of the formulations. To calculate the required ingredient quantities, the flowable liquid-retention potentials (Φ-values) of powder excipients were used.7 and 8 Flowable liquid-retention potential for Avicel PH 102 and Aerosil 200 was 0.16 and 3.33 respectively.9 The liquid load factor was computed from the flowable liquid-retention potential in accordance with equation

(1) using an R value (excipient ratio). equation(1) Lf=Φ+Φ(1/R)Where, check details Lf–liquid load factor Φ – Flowable liquid retential potential of carrier The most suitable quantities of carrier (Q) were calculated using equation (2). equation(2) Lf=W/QLf=W/Q W – Weight of liquid medication The optimum quantities of carrier (Q) and coating material (q) were obtained from equation (3) equation(3) R=Q/qR=Q/q q – Amount of coating material Table 2 shows composition of different candesartan cilexetil liquisolid compacts according to mathematical model and 32 factorial design. The flow properties of the liquisolid systems were estimated by determining the angle of repose, Carr’s index, and Hausner’s ratio. The angle of repose was measured by http://www.selleckchem.com/products/dinaciclib-sch727965.html the fixed funnel and free standing cone method. The bulk density and tap densities were determined for the calculation of Hausner’s ratio and Carr’s Index.10 and 11 DSC was performed in order to assess the thermotropic properties by using differential scanning calorimetry (Model: SDT2960, universal V2.4F TA Instrument USA). About 5 mg of the sample were sealed

in the aluminium pans and heated at the scanning rate of 10 °C/min, covering a temperature range of 80 °C–330 °C under nitrogen atmosphere. For characterization of crystalline state, the X-ray powder diffraction studies were carried out by using, Philips analytical X-Ray diffractometer (Model: PW3710, Holland),with a copper target, at a voltage of 40 kV and current of 30 mA. The scanning angle ranged from 5 to 70° of 2° about and the counting rate was 0.4 s/step. Morphological evaluation of the pure Candesartan cilexetil and one liquisolid compact which shows the highest dissolution rate was carried out by JSM-6400 scanning electron microscope (JEOL, Tokyo, Japan). FTIR spectra of candesartan cilexetil and one formulation which showed highest dissolution rate were recorded on Shimadzu FTIR-8400 spectrophotometer (Shimadzu Corporation, Kyoto, Japan). The hardness of the liquisolid compacts was evaluated by using Monsanto hardness tester. Friability test was performed by using Roche friabilator (Electrolab, Mumbai, India.