goal is the maintenance of genomic stability t and ultimately prevent. Transformation into cancer cells The checkpoint For the formation of the mitotic spindle is particularly important because it SGX-523 aneuplo the first line of defense against the m Possible development of a clone Is, and it is the embroidered chromosome segregation properly. Among the kinases that regulate many points and embroidered known to the family of serine-threonine kinases as Aurora is always an embroidered their extremely important cell division, leading to much t for the maintenance of genomic stability. The aberrant expression of one or more of the three members of the Aurora family has been observed in many solid and h Dermatological cancers. As for HCC, overexpression of Aurora B kinase, which regulates specific chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore and microtubules correlates kinetochore good anchoring itself with genetic instability And HCC t as independent Ngiger Pr Predictor of FBK Cases in this art identified by cancer.
We k Can assume, therefore, that a number of small molecules with inhibitory activity t Against Aurora kinase, particularly the Aurora B kinase mostly in the phase Trials in various solid tumors k do Nnte good candidates for use in HCC. IGF catenin and Wnt signaling pathways IGF family that plays an r Important role in the regulation of many normal cellular Ren functions, also in the development of many cancers associated. In HCC, although IGF Potentially Cyt387 improve cirrhosis, as suggested by some experimental, IGF Seems to be overexpressed in about 30 human HCC, w While IGF-binding proteins that act as oncosuppressors k Can be downregulated. Insulin oncosuppressor as growth factor receptor especially useful at the IGF involved Binding and degradation is downregulated in a subset of HCC, sixth as a direct result of deletion mutations in the long arm of chromosome Many compounds targeting IGFR two monoclonal body and small molecules are currently being tested in various solid tumors.
As for the Wnt catenin activation in the pathogenesis of more than one third of HCC, especially those that HCV, which makes this route very interesting from a therapeutic point of view has been implicated. However, this pathway is currently considered the worst possible candidate for the development of drugs that they defined at all levels and was therefore considered undruggable. The S Acid receptor retino 101 4 TAC that benzo Surely that is one of the most interesting compounds in HCC is tested. TAC 101 is a retino Synthetic oral administration to retino receptor binds Active and that its transcriptional activity of t. What l st Many biological events, such as the stimulation of cell differentiation compound inhibiting the phosphorylation of the retinoblastoma gene product, and cell cycle arrest. Latter