“Powassan virus is a rarely diagnosed cause of encephaliti


“Powassan virus is a rarely diagnosed cause of encephalitis, and is associated

with significant neurologic sequelae. Although symptomatic infections with Powassan virus occur primarily in adults, we report a case of confirmed Powassan neuroinvasive disease in a child presenting to a Tennessee hospital, with symptoms and imaging studies suggestive of acute disseminated encephalomyelitis.”
“In recent years polarization fatigue in ferroelectric polymers has attracted much attention due to their potential use in nonvolatile memories, though the mechanism is still an open question. Here we mainly focus on the experimental observations on two physical phenomena occurring during fatigue process: The frequency dependence of the fatigue rate Nepicastat and the change in the coercive field with increased fatigue cycles. The frequency dependence of fatigue rate shows that at lower fatigue frequencies the rate obeys a universal scaling behavior with respect to N/f, where N is the fatigue cycles and f is the fatigue frequency, while at much higher frequencies this scaling behavior is broken and the fatigue rate is N/f dependent. In addition, both the increase and the decrease of the coercive field are observed, which ACY-241 indicates that the change in the coercive field should be dominated

by different mechanisms. Based on the understanding of the crucial influence of space charges on electrical fatigue, we give a detailed discussion on both phenomena. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3607316]“
“The PDGFR inhibitor protective role of exogenously supplied selenium (Se) and polyamines (PAs) such as putrescine (Put) and spermine (Spm) in detoxifying the cadmium (Cd) induced toxicity was studied in the marine red alga Gracilaria dura in laboratory conditions. The Cd exposure

(0.4 mM) impede the growth of alga while triggering the reactive oxygen species (ROS viz. O-2(center dot-) and H2O2) generation, inhibition of antioxidant system, and enhancing the lipoxygenase (LOX) activity, malondialdehyde (MDA) level and demethylation of DNA. Additions of Se (50 mu M) and/or Spm (1 mM) to the culture medium in contrast to Put, efficiently ameliorated the Cd toxicity by decreasing the accumulation of ROS and MDA contents, while restoring or enhancing the level of enzymatic and nonenzymatic antioxidants and their redox ratio, phycobiliproteins and phytochelatins, over the controls. The isoforms of antioxidant enzymes namely superoxide dismutase (Mn-SOD, similar to 150 kDa; Fe-SOD similar to 120 kDa), glutathione peroxidase (GSH-Px, similar to 120 and 140 kDa), glutathione reductase (GR, similar to 110 kDa) regulated differentially to Se and/or Spm supplementation. Furthermore, it has also resulted in enhanced levels of endogenous PAs (specially free and bound insoluble Put and Spm) and n-6 PUFAs (C20-3, n-6 and C20-4, n-6).

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