J Clin Microbiol 2012,50(7):2299–2304.PubMedCrossRef 35. Liu H, Rodes B, George R, Steiner B: Molecular characterization and analysis of a gene encoding the acidic repeat protein (Arp) of Treponema pallidum . J Med Microbiol 2007,56(Pt6):715–721.PubMedCrossRef 36. Harper KN, Liu H, Ocampo PS, Steiner BM, Martin A, Levert K, Wang D, Sutton M, Armelagos GJ: The sequence of the acidic repeat protein ( arp ) gene differentiates venereal
from nonvenereal Treponema pallidum subspecies, and the gene has evolved Belnacasan cost under positive selection in the subspecies that cause syphilis. FEMS Immunol Med Microbiol 2008,53(3):322–332.PubMedCrossRef 37. Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA: Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody
and protective immune response. J Exp Med 1999, 189:647–656.PubMedCrossRef 38. Stamm LV, Greene SR, Bergen HL, Hardham JM, Barnes NY: Identification and sequence analysis of Treponema pallidum tprJ , a member of a polymorphic https://www.selleckchem.com/products/NVP-AUY922.html multigene family. Cell Cycle inhibitor FEMS Microbiol Lett 1998,169(1):155–163.PubMedCrossRef 39. Giacani L, Molini B, Godornes C, Barrett L, Van Voorhis W, Centurion-Lara A, Lukehart SA: Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis. Infect Immun 2007,75(1):104–112.PubMedCrossRef 40. Giacani L, Centurion-Lara A, Lukehart SA: Length of guanosine homopolymeric repeats modulates promotor activity of subfamily II tpr genes selleckchem of Treponema pallidum ssp. pallidum . FEMS Immunol Med Microbiol 2007,51(2):289–301.PubMedCrossRef 41. Cox DL, Luthra A, Dunha-Ems S, Desrosiers DC, Salazar JC, Caimano MJ, Radolf JD: Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum . Infect Immun 2010, 78:5178–5194.PubMedCrossRef 42. Giacani L, Godornes C, Puray-Chavez M, Guerra-Giraldez C, Tompa M, Lukehart SA, Centurion-Lara A: TP0262 is a modulator of promotor activity of the tpr Subfamily II genes
of Treponema pallidum ssp. pallidum . Mol Microbiol 2009,72(5):1087–1099.PubMedCrossRef 43. Leader BT, Godornes C, Van Voorhis WC, Lukehart SA: CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis. Infect Immun 2007,75(6):3021–3026.PubMedCrossRef 44. Van Voorhis WC, Barrett LK, Koelle DM, Nasio JM, Plummer FA: Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis 1996,173(2):491–495.PubMedCrossRef 45. Cruz AR, Ramirez LG, Zuluaga AV, Pillay A, Abreu C, Valencia CA, La Vake C, Cervantes JL, Dunham-Ems S, Cartun R, Mavilio D, Radolf JD, Salazar JC: Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments. PLoS Negl Trop Dis 2012,6(7):e1717.