ITMN-191 15-PGDH and VDR expression. COX-2 expression detected by Western blot analysis revealed a more than 4-fold increase in malignant breast tissue compared to normal breast tissue . Malignant ovarian tissue had a more than 2-fold COX-2 protein level compared to normal ovarian tissue . The protein levels in ovarian tumor samples of 15-PGDH were 80-fold higher compared to normal tissue samples . The protein levels of 15-PGDH were significantly higher in malignant breast tissue compared to healthy tissue . The VDR expression was reduced in breast cancer tissues compared to normal tissues and was also reduced in ovarian cancer tissues compared to normal tissue .

These results demonstrated an inverse correlation of the COX-2 and 15-PGDH with VDR  Orotic acid protein expression changes in cancer tissues. Cordes et al : Serum PGE 2 and Vitamin D Receptor Levels in Breast and Ovarian Cancer Figure COX-2 and VDR expression in malignant breast tissues compared to normal tissues. In malignant tissue samples protein expression of COX-2 is increased and VDR protein is decreased compared to healthy ovarian tissues. Differences were significant at p<0 Figure COX-2 and VDR expression in malignant ovarian tissues compared to normal tissues. In malignant tissue samples protein expression of COX-2 is increased and VDR protein is decreased compared to healthy ovarian tissues. Differences were significant at p<0 D 3 and PGE 2 serum levels in healthy women, and breast and ovarian cancer patients. In breast tissue, we observed significant differences in women older than 45 years, among these with and those without breast cancer, diagnosed during wintertime . Healthy women purchase Afatinib had significantly higher serum levels of D 3 than women with breast cancer .

We also detected a reduction of the serum levels of D 3 in ovarian cancer tissues compared to healthy women but it was not statistically different . PGE 2 levels in breast cancer patients were higher compared to healthy women . The PGE 2 levels were also significantly higher in ovarian cancer Figure Serum levels of 2 D 3 and PGE 2 from women with breast cancer compared to healthy women during wintertime. While serum levels of 2 D 3 are decreased in blood samples from women with ovarian cancer against healthy  order Gynostemma Extract patients, serum levels of PGE 2 are increased. Differences were significant at p<05; p<0 Figure Serum levels of 2 D 3 and PGE 2 from women with ovarian cancer compared to healthy women during wintertime. PGE 2 levels in blood samples from women with ovarian cancer are increased against healthy patients. Differences were significant at p<0 patients older than 45 years than in healthy women of the same age .

We did not find any significant difference in PGE 2 levels in women younger than 45 years. PGE 2 receptor EP 2 and EP 4 expression. A significant reduction of EP 2 protein level  wavelength was found in malignant tissue samples as compared to healthy tissue samples . Moreover, we also detected a significantly lower level of EP 4 protein.