In addition, all subjects received transdermal nicotine replaceme

In addition, all subjects received transdermal nicotine replacement for 8 weeks following their quit date and brief smoking cessation counseling throughout the entire treatment

period. We hypothesized that participants who received naltrexone would report higher rates of abstinence from cigarette smoking and lower post-quit weight gain compared to participants who received placebo. One hundred seventy-two cigarette smokers were enrolled. Recruitment was via advertisements placed in local media outlets, mailings (to past participants, potential participants, and health care professionals), fliers, fax referrals from healthcare providers, press see more releases, and websites. To be eligible, all smokers needed Saracatinib to be classified as weight-concerned smokers based on 2 criteria. Concern about gaining weight after quitting was assessed using the questions Perkins et al. (2001) used to define weight

concern in their clinical trial of CBT. These included “How concerned are you about gaining weight after quitting?” and “How concerned would you be if quitting smoking caused you to permanently gain 10 lbs?” Consistent with their criteria, a rating of 50 or higher on a 100 mm scale on either question qualified the subject on this criterion. Smoking to manage weight was assessed with the weight

control subscale of the Smoking Consequences Questionnaire [SCQ] (Copeland et al., 1995) on which participants rate their expectations about the consequences of smoking a cigarette on a scale of 0-9 with 1 being “completely unlikely” and 9 being “completely likely”. Five items make up this subscale (alpha = 0.96) and include “smoking keeps my weight down”, “cigarettes keep Parvulin me from eating more than I should”, “smoking helps me control my weight’, “cigarettes keep me from overeating”, and “smoking controls my appetite”. A mean rating of 6 or above (“somewhat likely”) qualified participants on this criterion. Other inclusion and exclusion criteria were age 18 and older, willingness and ability to give written consent, smoking greater than 10 cigarettes per day for at least 1 year, at least 1 prior attempt to stop smoking, baseline expired carbon monoxide (CO) level of at least 10 ppm, weight of at least 100 lbs, English speaking, and only 1 participant per household.

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