Gastrointestinal side effects e, ritonavir is associated with nausea and vomiting. This study examines whether fighting Scutellaria baicalensis and its active component flavonoids, baicalein, the gastrointestinal effects HDAC of ritonavir to d. Effects of grass feeding was evaluated in rats with a rat pica model ritonavir, the nausea and vomiting simulated humans. The effects of administration of Kr Utern on gastric emptying in rats were also measured. Ritonavir treatment went Born f Depends kaolin or severe pica, whose intensity was reduced t fa They significantly with S. baicalensis administration. High-performance liquid chromatographic analysis showed the presence of S. baicalensis one ingredient extremely POWERFUL Hige flavonoids baicalein.
The study aimed to determine whether baicalein contributed in the fight against greenhouse gas pica extract. It was Tivozanib observed that baicalein dose- Ngig reduced pica treated rats with ritonavir. Zus Pica causing tzlich, ritonavir also significantly gastric emptying, the ritonavir-induced gastrointestinal dysfunction can help k Galv Siege. If S. baicalensis extract was administered to rats treated with ritonavir gastric emptying was significantly attenuated Cht. The results suggest that S. baicalensis and component baicalein reduce gastrointestinal dysfunction caused by ritonavir. It is concluded that S. baicalensis may potentially ask a him play in the reduction of drug-induced side effects. Introduction of protease inhibitors are h Frequently used, powerful anti-HIV drugs that act by inhibiting viral replication.
Drugs in this class, especially ritonavir, k Can unpleasant side effects such as gastrointestinal nausea and vomiting. Ritonavir is currently used in the treatment of HIV-rings in addition to other protease inhibitors ritonavir inhibits the enzyme from liver CYP3A used thereby. The plasma concentration and bioavailability of other antiviral drugs Although the dose of ritonavir for the adjuvant effects is less than that required for a direct antiviral effect required, nausea and vomiting continue to be reported in at least 20% of patients. Recent research on the pharmacological effects of other protease inhibitors have their F Ability to stimulate the release of reactive oxygen species in cultured cells demonstrated. Protease inhibitor ritonavir and other stimulate cultured endothelial cells, above the Strength amounts of superoxide radicals produce entered Ing Zellsch And the dysfunction.
Have recently published data suggest that ritonavir, oxidative stress in the human Body to increased hen. Since oxidative Sch Ending of the gastrointestinal mucosa has been been linked to the release of serotonin, and nausea and vomiting due, it was postulated that cause ritonavir k Can gastrointestinal side effects due to a Hnlichen mechanism. nausea and vomiting caused by oxidative caused etiology sensitive. to treatment with antioxidants Thus, the treatment with herbal antioxidants mitigate the effects induced gastrointestinal ritonavir. The present study examined the effect of Scutellaria baicalensis treatment, and its drug baicalein, Ritonavir effects on gastrointestinal side effects with two rat models, the pica model and the model of gastric emptying. Materials and Methods Anima