Aurora kinase A powerful Sede inhibitionwith an IC50 of 48 Nm / L with limited Nkter or Aurora B kinase C inhibition.55 Pr Clinical data demonstrate the effectiveness of AML, myelodysplastic syndrome, CML epigallocatechin (-)-Epigallocatechin gallate and ALL.55 A phase I study, 37 patients were treated at 7 dose levels.56 pharmacokinetic evaluation of the parent drug and its metabolite, showed a short half-life of 2.4 4.9 hours. The effect of a given dose was 8 hours after taking the dose considerably, but lacking in 12 hours.

Neutropenia, the DLT occurred in 24% of cycles. Eight of 31 patients with AML shows a 50% reduction in the explosions, in both occurring wild-type FLT3 and FLT3-mutated patients. Demonstrated in a patient with CML T315I BCR Abl one completely Requests reference requests getting disappearance of the T315I mutant clone.
The authors conclude that KW is tolerable Acadesine in 2449 and produced an objective response, but needs three to four daily doses sufficient to maintain plasma levels. Phase I trials in malignant h Dermatological diseases is currently underway.28 3.0 Aurora B kinase inhibitors Hesperadin Hesperadin 3.1 an AKIS the first discovered and played an R In fully understand the r From the Aurora B kinase and spindles. Drug development was abandoned after it was discovered that cells develop PLO Aberrant die hesperadin exposed, but not Lebensf lose Ability or apoptosis. Currently hesperadin used as a laboratory tool to probe the kinase Aurora B. 3.1.1 BI811283 is a potent inhibitor of the kinase Aurora B showed antitumor activity BI811283 t in several mouse xenograft models, including cancer, non-small cell lung cancer and colorectal cancer.
57, 58 The MTD was determined models by continuous infusion at 20mg/kg once a week. In addition, evidence of polyploid Senescence and has been within 48 hours and 96 hours respectively identified. Two doses were tested performed in Phase I trials in patients with advanced solid tumors.59 same time, 60 h continuous infusion administration BI811283 24 on day 1 every 21 days was an MTD of 230 mg DLT neutropenia.59 seen with stable disease and was the best response in 19 of 57 patients recruited. Administration of BI 811 283 24 h infusion on days 1 and 15 is determined by a treatment cycle of 28 days, reported that 140 mg MTD.60 In this study of 52 patients with neutropenia, the DLT was stable disease as best response in 15 of 52 patients.
Although both timing was not compared with each other, the two samples allowed to be administered to an average of three cycles. Current phase I trials of two administrative are Zeitpl Ne ongoing.28 3.1.2 AZD1152 AZD1152 is a highly selective inhibitor of the kinase Aurora B, w While without the Morgenr-run A-kinase inhibition at clinically relevant doses. AZD1152 is a pro-drug in plasma is rapidly active in the unit, AZD1152 HQPA converted, where Bl skirts of F If the competitive position of ATP-binding pocket of Aurora kinase B. Pr Clinical studies of human tumor cultures and were single agent in mouse xenograft models with AZD1152 conducted in many tumor types, including breast61, 62, pancreas62, colorectal62, 63,64,65, 66, non-small cell lung63, 64, lung67 small cell lung, hepatocellular Ren carcinoma68 myeloma, malignant mesothelioma69, AML62, 70,71,72 and 73 more. AZD1152 is a potent inhibitor of FLT3, m for may have by a double anti-tumor effects in AML.74