Electrophoretic migration was middle part of the gel. Bands corresponding to large, buoy ant LDL particles showed clear increase in intensity after treatment with insulin inhibitor Pfizer analogs. Figure 1B and 1C are de monstrative densitometric scans of before and after treat ment with insulin analogs, respectively. A significant increase in LDL 1 fraction and a significant decrease in LDL 2, LDL Inhibitors,Modulators,Libraries 3 and LDL 4 fraction were seen after treat ment with insulin analogs. Statistical analysis was done by paired t test. Changes in HDL subfraction pattern Figure 2A shows 6 gel tubes following completion of electrophoresis. Electrophoretic migration was from the top of the tube to the bottom. Separation was achieved via particle size based on the sieving action of the gel.
Inhibitors,Modulators,Libraries LDLVLDL was the slowest migrating band while albumin migrated to a further distance. The HDL particles were separated in the middle part of the gel. Bands corresponding to large and intermediate HDL par ticles showed clear increase in intensity after treatment with insulin analogs. Figure 2B and 2C are demonstrative densitometric scans of before treatment and after treat ment with insulin Inhibitors,Modulators,Libraries analogs, respectively. A significant in crease in HDL large . HDL intermediate and a significant decrease in HDL small fraction were seen after treatment with insulin analogs. Statistical analysis Box plot graph data of CETP and LCAT protein content and activity are shown in Figure 3. The boundary of the box closest to zero indicates the 25th percentile, the line within the box marks the median, and the boundary of the box farthest from zero indicates the 75th percentile.
Whiskers above and below the box indicate the 90th and 10th percentiles. Inhibitors,Modulators,Libraries CETP protein measured after treatment with insulin analogs was signifi cantly increased compared to before treat ment level. Statistical from the top of the tube to the bottom. Separation was achieved via particle size based on the sieving action of the gel. Chylomicrons remained in the loading gel, VLDL was the slowest migrating band while HDL Inhibitors,Modulators,Libraries migrated to a fur ther distance. The LDL particles were separated in the analysis was done by Wilcoxon Signed Rank Test. Simi larly, CETP activity measured after treat ment with insulin analogs was significantly increased compared to be fore treatment. Statistical analysis was done by paired t test.
No significant difference was observed in LCAT pro tein level before and after treatment with insulin analogs with measured level of add to your list 11. 93 2. 93 and 12. 94 3. 05 ugml, respectively. Similarly, no significant difference was observed in LCAT activity before and after treatment with insulin analogs with measured ratio of 390470 nm fluorescence emission intensities of 1. 36 0. 14 and 1. 30 0. 22, re spectively. Apolipoprotein A1 and B levels Apolipoprotein B level measured after treat ment with insulin analogs was signifi cantly decreased compared to before treatment.