Ity the results. The MIC of each agent for each isolate are listed in Table 1. All strains 12 St Pneumoniae with the exception of quinolone-resistant strain was S. anf Llig for levofloxacin. Breakpoints for ABT 492 have not been established, however, showed that BSI-201 Iniparib ABT 492 activity were strong t against all bacterial isolates for which MIC 0.125 g / ml against S. pneumoniae, the MIC of ABT 492 ranged from 0.0078 to 0.125 g / ml against 1 to 32 g / ml for levofloxacin. H. influenzae and for M. catarrhalis, the MIC of ABT 492 were much lower and was 0.000625 to 0.0025 g / ml, compared with 0.0156 to 0.0625 g / ml for levofloxacin. Reporting anti-bacterial. A carryover effect was observed in all isolates of S. pneumoniae to eight times the MIC, independent Ngig of the quinolone tested.
With four times the MIC, the entire transmission has been eliminated, except for a slight delay Gerung was four times the MIC of ABT observed 492 for quinolone-resistant S. pneumoniae isolate. M Possible transmission exists, when direct removal Testr Hrchen was inoculated for one h Here multiple of the MIC, however, 0.1 ml aliquots were immediately spread on agar plates containing 25 ml medium. 17-AAG This reduced the carryover by causing a 1:250 dilution of the antibiotic. Report has not been seen in H. influenzae and M. catarrhalis isolates. Response Effect of concentration. The inoculum from average concentrations of all the dead-time curves is 5.813 log 10 CFU / ml when all 12 isolates on the basis of Ausma Is the removal of bacteria were compared, ABT 492 and levofloxacin demonstrated at eight times the MIC bactericidal activity t against all isolates.
ABT 492 and levofloxacin at four times the MIC was bactericidal against 83% and 100% of the isolates, respectively. A bacteriostatic effect was between one and two times the MIC for many isolates. A delay Storage in bacterial growth as compared to the control was at 0.25 and 0.5 times the MIC was observed. If the time data were separated according to Species of bacteria kill, not ABT isolate 492 to bactericidal activity at four times the MIC for the quinolone resistance and to generate an S pneumoniae isolate resistant to penicillin. At twice the MIC was bactericidal against pneumoniae ABT 492 in 20% to 100% for levofloxacin, p is based. Regrowth was not tested in 492 isolates seen, but ABT has been tested in a levofloxacin occurred penicillin of S.
pneumoniae sensitive. The time kill kinetic data for H. influenzae and M. catarrhalis Were similar for both ABT 492 and levofloxacin. The concentrations of four and eight times the MIC produced bactericidal activity of t in all St Strains. Table 1: twice. MICs for all tests and the strain isolated organism MIC levofloxacin ABT 492 penicillin susceptible S. pneumoniae strain 1 0.0078 a penicillin-susceptible S. pneumoniae strain 2 0.0078 a penicillin-resistant S. pneumoniae strain 1 0.0156 a penicillin-resistant S. pneumoniae strain 2 0.0078 a quinolone-resistant S. pneumoniae 32 .125 lactamase positive H. influenzae strain 1 0.00125 0.0156 lactamase-positive H. influenzae strain 2 0.000313 0.0156 lactamase -negative H. influenzae strain 1 0.000625 0.0156 lactamase-negative H. influenzae strain 2 0.000625 0.0156 lactamase-positive M. catarrhalis strain 1 0.0025 0.0625 lactamase-positive M. catarrhalis strain 2 0 , 0025 M. catarrhalis strain lactamase 0.0625 1204 0.001 0.0313 Gunderson et al. Antimicrob. Agents Chemother. The MIC was bactericidal activity of t observed