Y Antique Body antiRyR independently Ngig, taking into account other potential Asiatic acid rfaktoren St, Such as thymectomy and stero Of. Tacrolimus levels before treatment C, ngml, mgkg t adjusted Doses and concentrations pretreatment dosenormalized Cdose, ngml by mgday per kg Were atweek body weight from medical records, months, months after transplantation retrieved andyear. Tacrolimus blood levels were systematically measured with an immunoassay analyzers performed with a t Cobas Mira plus, Roche Diagnostics, Basel, Switzerland. Renal function was Sch Tzung the glomerular Evaluated Ren filtration rate GFR from serum creatinine over the Change variable Ern Currency in renal disease formula GFRCr Age. if black if there is a woman.
Dir Gerter DGF graft function was defined according to standard criteria, Andor clearancemlmin creatinine in the first days after transplantation, the need for dialysis may need during the first postoperative week. CNIT was eingeschr by experienced nephrologists to i Nkter kidney function by increasing Valuesincrease increase in serum creatinine ATPase pathway of numbers defined basal joint diagnosed Ncidant with a high plasma tacrolimus with subsequent Final acceptance after the dose reduction Andor ii exclusion of renal failure as a result of the biopsy-proven acute repulsion UNG Andor is assessed by clinical judgment when patients presented with an increase mgdl serum creatinine is common wrong with supratherapeutic concentrations before treatment with tacrolimus, fever without signs of infection, graft, or swelling, oliguria, increases hte resistance index for ultrasound Doppler or clinical response to treatment with stero compatible with the rejection.
The acute repulsion UNG was established by histological findings of kidney biopsies as theBanff by Andor clinical evaluation described above classified. The diagnosis was confirmed by biopsy in all patients steroid-resistant The best Saturated. Define the symptoms that Neurotoxizit t: Tremors, headaches, insomnia, hyper Anesthesiology, itching and Kr vapors. Follow the protocol in our center, patients were specifically asked about the presence of neurological symptoms. Blood samples were analyzed for genotyping was obtained from each patient, immediately stored atc until genotype analysis. Genomic DNA was isolated from peripheral blood leukocytes in each compartment by the sample is whole blood method a QIAamp DNA Blood Qiagen Inc.
, Chatsworth, CA, USA. Each reaction Not polymerase and RFLP analysis were used to fluctuations according CYPAB, CyPA, and CYPC CYPJ determine the ones described above. The analysis of the sample index has been duplicated and best justified By sequential Age living. The three most important polymorphisms ABCB n, Namely CT, CT-A and GT sequences were determined by the cords Live ABI Genetic Analyzer, Applied Biosystems, Weiterstadt, Germany detected using the primers and PCR conditions described above. The statistical analysis was the distribution of the outcome variables through the test of normality KolgomorovSmirnov t test. The statistical significance of differences in the quantitative variable concentrations before treatment was the dose doseadjusted requirements, creatinine values, etc., among people with different genotypes using the anovaBonferroni KruskallWallis test or, if available. If o