Although it has long been demonstrated that bimanual motor performance is mediated by the function

of the CC (Preilowski, 1972; Franz et al., 1996; Eliassen et al., 1999, 2000; Stephan et al., 1999; Serrien et al., 2001; Kennerley et al., 2002; Diedrichsen et al., 2003; Johansen-Berg et al., 2007; Muetzel et al., 2008), little is known about the neural activity of the transcallosal circuit during bimanual motor actions (Soteropoulos & Baker, 2007). Recently, Yedimenko & Perez (2010) demonstrated that interhemispheric inhibition, as assessed by paired-pulse TMS, is modulated according to the direction of static forces Serine Protease inhibitor of bilateral index fingers. Our experiment further expands this notion to the dynamic regulation of bimanual forces. In the present study, we demonstrated that TCI between the motor cortices was modulated according to the condition of bimanual force regulation. TCI was greater when bimanual www.selleckchem.com/products/VX-809.html force regulation was performed in a symmetrical manner compared

with when it was performed in an asymmetrical manner. In line with this, the perturbation of force tracking performance induced by TMS over the ipsilateral M1 was greater during the symmetric condition than during the asymmetric condition. Therefore, the transient disruption of right M1 activity due to TCI could mainly account for the modulation of the left tracking disturbance. Furthermore, our findings could be a manifestation of the specific neural organization of the transcallosal inhibitory circuit for bimanual force control. Although TCI showed a different magnitude depending on whether TMS was applied during the left force incremental phase or decremental phase, the magnitude of TCI was generally larger during the symmetric condition than during the asymmetric condition, irrespective of the tracking phase. In addition, TCI of tonic muscle contraction was not modulated by unimanual

force regulation of the right thumb (Fig. 4). These findings demonstrated that simultaneous force regulation with different coordination conditions accounts for the observed modulation STK38 of TCI, but unilateral force regulation was insufficient to induce such modulation. The most important finding in the present study was that TCI during the symmetric condition, which required synchronous bilateral force regulation of the thumb, was greater than during the asymmetric condition. However, this finding may not be in line with the accepted role of TCI between the motor cortices. During a unimanual action, one of the most important functions of TCI is to prevent unwanted motor activity of the muscles contralateral to the acting hand (Mayston et al., 1999; Duque et al., 2007; Hübers et al., 2008; Giovannelli et al., 2009). Accordingly, this consideration might lead us to predict that TCI is weaker during symmetric muscle contractions than during asymmetric muscle contractions (Meister et al., 2010).