Absorbable mesh can be used similarly to the Wittman patch,

stitching it to the fascia and slowly bringing the fascial edges together during serial returns to the operating room as the visceral edema resolves with primary closure rates of 22-38% [42, 50, 51]. If unable to close the fascial defect with progressive closure techniques, the operative plan must shift gears to one of an expectant hernia (Figure 1). Patients with residual fascial defects should be covered with split thickness skin Selleckchem Temsirolimus grafting once the viscera are fixed and granulation tissue is sufficient [42, 50, 51]. Because of the high risk of infection, synthetic graft material should be removed prior to skin grafting [49]. this website Figure 1 Example of a patient’s abdominal wall with planned ventral hernia

after vicryl mesh placement and split thickness skin grafting. Formal reconstruction of the ventral hernia should be deferred until after the patient has fully recovered and is ready for another large operation. Timing of the definitive repair is not well studied, Jernigan et al., recommend 6–12 months but no longer as they found less need for prosthetic bridging and lower recurrence rate due to more tension free repair in patients operated on earlier than 12 months. Component separation may be required to span the defect; there are multiple methods for this procedure with good outcomes reported [51]. In clean fields, synthetic mesh may be utilized as a bridge if the patient cannot be closed primarily with or without component separation. Another option to close the fascial defect is to use a biologic CUDC-907 mouse material, such as human acellular dermal matrix (HADM). This has the benefit of being an option in a contaminated or infected field. As described by Nitroxoline Scott et al., the HADM is fixed transfascially with 2-3 cm of underlay, with multiple pieces stitched together if necessary. The repair should be taut to reduce laxity. If the skin edges can be mobilized and closed, closed suction drains are left to manage the dead space; otherwise a non-adherent dressing is

placed over the HADM and a negative pressure dressing is applied [78]. Two series looked at this method [78, 79] and reported good outcomes, but with concern for recurrent hernia and eventration. Recommendations We recommend 1. Damage control laparotomy for trauma or acute general surgical patients under physiologic stress including; acidosis, hypothermia, hypocoagulable state, prolonged hypotension. Also, those requiring a “second-look” after ischemic or embolic events or intra-abdominal infections which may need additional debridement such as necrotizing pancreatitis.   2. Initial abdominal closure should employ a negative pressure dressing such as the “vacuum pack” method or its commercially available alternative.   3.