6/10 (95% CI 6.92–8.28). In the high dose group 86.4% were satisfied with treatment with an

mean satisfaction score of 8.5/10(95% CI 7.3–9.50). When asked if they would consider repeat botulinum toxin A treatment if needed 81.0% (47/58) of the low dose group stated they would, compared to 86% (19/22) in the high dose group. The average reported number of repeat treatment sessions prior to contemplating surgical intervention was 1.4 (95% CI 1.2–1.7, range 0–3) in the low dose group compared to 1.5 (95% CI 1.2–1.8, range 0–3) in the high dose group. Efficacy was better when treated with high dose botulinum toxin A. Significantly fewer patients had recurrent symptoms of CAF in the high dose group (27.3% vs. 53.4%, P = 0.04) and there was a statistically significant reduction in the rate of surgical BVD-523 mw management of CAF following high dose botulinum toxin A treatment (4.5% vs. 8.6%, P < 0.05). Conclusion: This study reveals that high dose botulinum toxin A has a similar safety profile to low dose treatment; there is no significant increase in bleeding or incontinence. Pain from CAF is shown to be significantly improved following high dose treatment. High dose botulinum toxin A also demonstrates a significant reduction in the recurrence

of CAF disease and surgical intervention rate is significantly less. The rate of post procedure complication with high dose botulinum toxin A (80–100 IU) demonstrated in this study is less than current published data of surgical intervention for CAF. The majority of patients treated with

botulinum toxin A for CAF are willing CDK inhibitor to have repeat treatment for recurrent episodes prior to planning surgical intervention. This indicates Bcl-w the importance of chemical sphincterotomy in CAF disease. CJ SHUTTLEWORTH,1 M HALLAND,2 K BRISCOE3 1Basic Physician Trainee, St George Hospital, Sydney, Australia, 2Department of Gastroenterology, Mayo Clinic, Rochester Mn, 3North Coast Cancer Institute, Coffs Harbour, Australia Introduction and Cases: Carcinoid is typically considered a sporadic disease and little is known about its hereditary forms. There is growing evidence that familial Carcinoid exists outside its classical association with syndromes of Multiple Endocrine Neoplasia (MEN). Novel oncogenes have been identified associated with autosomal dominant forms of Ileal Carcinoid, leading to the emergence of “Familial Ileal Endocrine Carcinoma” (FIEC). 1. Here we present the case of two brothers recently diagnosed with small bowel Carcinoid as well as a systematic review of the literature. Case One: Mr. AB, a 51 year old man, presented in 2012 with a four year history of increasing abdominal pain and minimal diarrhoea without flushing. He was one of ten siblings and interestingly one of his brothers had died from an unknown abdominal malignancy several years prior.