34 °C. The pure polymer Cellulose Acetate exhibits a peak at 237.15 °C. The peak of Glibenclamide was observed in Pfizer Licensed Compound Library ic50 the thermogram of prepared microparticles, thus the results revealed that there were no major interactions between the drug and the polymer during microencapsulation process. The DSC thermograms were shown in Fig. 3. The prepared microparticles exhibited good flow properties. The use of the surfactant permits the remarkable reduction in the size of the microparticles as the result of decrease in the interfacial tension. Microscopic examination of the formulations revealed that the microparticles were spherical and appeared as aggregates or discrete particles. All formulations

had a narrow particle size distribution. The particle size of the microparticles ranged between 132.54 μm and 178.44 μm. The micromeritic parameters were tabulated in Table 2. The % yield of microparticles prepared by solvent evaporation technique was found in the range of 90.25–98.75. The technique also showed good entrapment efficiency. The % yield, drug content and encapsulation efficiency data shown in Table 3. The SEM studies clearly showed that the obtained microparticles exhibited good spherical nature and the SEM photographs were shown in Fig. 4 The microparticles were

subjected to In-vitro release studies by employing 7.4 pH phosphate buffer and the drug release profiles were shown in Figs. 5 and 6. When the amount of drug release Sorafenib in vitro values were plotted against time straight lines were obtained in all the cases indicating that the rate of drug release from these microparticles followed Dipeptidyl peptidase zero order kinetics and the graphs were shown in Figs. 7 and 8. To ascertain the mechanism of drug release from various microparticles plot of log %Released vs log time (peppas plots) were drawn. The plots were found

to be linear with all microparticle formulations. The peppas plots were shown in Figs. 9 and 10. Release Kinetics of Glibenclamide microparticles were shown in Table 4. The exponential coefficient (n) values were found to be in between 0.8162 and 1.182 indicating non Fickian mechanism. These results indicated that the release rate was found to decrease with increase in concentration of coating material applied. The wall thickness of microparticles was found to be increased with the increase in concentration of coating material applied. There exists a good correlation ship in between wall thickness and release rate constant and the graphs were shown in Fig. 11. The stability studies were carried out for the prepared microparticles. After 3 months storage of formulations at 30 ± 2 °C, 65 ± 5% RH and 40 ± 2 °C, 75 ± 5% RH, values of all parameters like % drug content, % encapsulation efficiency were checked and found to be almost similar to the initial values. The drug dissolution profile was similar to the initial profile.