05) and 14-38% higher in the Surgical group (P < 0.05) compared to Controls. BMD correlated positively with the alpha angle measurements (R-2 = 0.44, P < 0.001).

Conclusion: BMD was elevated in subjects with cam-type deformities, with the severity

of the deformity more correlative than symptom status. Similarities to the symptomatic group suggest that hips with an asymptomatic deformity may already be in early stages of joint degeneration. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“The phytochemical study of Duguetia moricandiana Mart. (Annonaceae) yielded the isolation of the alkaloid which was identified by spectral analysis as discretamine. The evaluation of antinociceptive activity ZD1839 molecular weight carried out by the acetic acid-induced https://www.selleckchem.com/products/ly3039478.html writhing, formalin and hot plate tests in mice, suggests a potent antinociceptive effect. Discretamine (5, 10 and 20mg kg(-1), i.p.) significantly reduced the number of writhes similarly at all doses tested and the number of paw licks during the first phase of formalin test when compared to control. The effect of discretamine on hot plate response provides a confirmation of its central effect. These

results indicate antinociceptive properties of this alkaloid.”
“Objective: To investigate the association between baseline hip shape and both clinical hip osteoarthritis (OA) and total hip replacement (THR) at CHIR-99021 5-year follow-up.

Design: Individuals from the Cohort Hip and Cohort Knee (CHECK) study, with early symptomatic OA, having standardized anteroposterior pelvic radiographs at baseline and 5-year follow-up (n = 723) were included. Hip shape on the radiographs was assessed using statistical shape modeling (SSM). Hips fulfilling the American College of Rheumatology (ACR) criteria at follow-up were classified as clinical OA. The association between each mode of shape variation and both outcome measures was calculated by Generalized Estimating Equations (GEE).

Results: The included individuals comprised 575 females

and 148 males (mean age 55.9 +/- 5.2 years). At baseline, 8% fulfilled the ACR criteria, 76% had no radiographic hip OA [Kellgren & Lawrence (K&L) = 0] and 24% had doubtful OA (K&L = 1). At follow-up, 147 hips (10.4%) fulfilled the ACR criteria and 35 hips (2.5%) had received THR. Five shape variants (modes) at baseline associated significantly with THR within 5 years. When combined in one GEE model, these shape variants resulted in a predictive power indicated by an area under the curve of 0.81. No shape variants associated with the presence of clinical OA at follow-up.

Conclusion: The shape of the hip as quantified by an SSM has a good predictive value for THR, whereas variation in shape cannot predict clinical OA. Minor shape variants may be used as a radiographic biomarker to predict the future risk of THR. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.