XAV939 Additional studies are warranted to provide support for the generalizability of these findings. Further, the sample sizes across studies are relatively small [19]. Thus, there is a high risk for confounding factors Cell Cycle inhibitor that may have skewed the data. For instance, an unmeasured characteristic of the men included within the present study like higher levels of the aromatase enzyme, may account for their lack of response to Resettin®.

Additional studies are warranted to more clearly delineate the association between Resettin® and serum testosterone levels. Findings from these studies are expected to improve the generalization of the conclusions. Notwithstanding, there was a measurable 38% GSK621 purchase increase in serum testosterone levels and a 4.5% decrease in estradiol among participants receiving the 1200 mg/day experimental group. Indeed, while this increase may not have reached the stringent criteria for statistical significance, this difference may be clinically relevant. Additional studies are warranted to

explore specific benefits to this degree of improvement in testosterone level. Moreover, given that serum DHT levels were significantly lower in both the 800 mg/day and 1200 mg/day treatment groups, and that Resettin®/MyTosterone™ has been shown to prevent the conversion of testosterone into DHT over time, it may be that this accounts for the rising testosterone levels in a subset of participants. Thus, additional studies that include a broader sample of study participants are warranted to explore for the generalizability of these findings. Future studies may also be needed to examine dosage level in relation to weight or BMI and androgen response. While weight specific dosing is not novel in terms of the pharmaceutical field, dietary supplements have not typically provided dosing instructions that are dependent upon the individual’s selleck chemical weight or BMI. It is expected that findings

from studies examining the impact of various dosages of Resettin®/MyTosterone™ on the metabolic profiles, specifically testosterone, DHT, and estrogen levels, across individuals who are overweight or obese will provide support for including weight dependent dosing instructions and, thus, improve the individual’s hormonal response to this natural dietary supplement. Additional studies are necessary to evaluate the full extent of the regulatory effects of Resettin® in the body’s efforts to resume homeostasis and return testosterone to ideal levels. This study highlights that there are likely ideal levels of testosterone in men. These data contribute to the possible benefits of using Resettin/Mytosterone for combating age-related androgen deficiency and andropause. Availability of supporting data There is no supporting data that is currently available. Acknowledgments M.L.A.