modulToxicity t. Many of them show broad spectrum modulatory effects on more than one ABC transporter of drugs. For instance, plant polyphenols and curcumin has been reported to modulate MDV3100 the three major ABC drug transporters: ABCB1, ABCC1 and ABCG2. Independent ngig from the source of the inhibitors unpredictable pharmacokinetic interactions involving multiple drug transporters in tumor tissues and the variability t the drug concentrations transporter expression between individuals, gr Stay ere obstacles restore use of modulators of drug sensitivity in the clinic. Other Ans tze INVERSION for MDR With the lack of success in multidrug resistance inhibition inhibitor use traditional medicines, the researchers con U to bypass new connections ABC transporters through a variety of mechanisms.
A popular method is to target mRNA. This can be antisense oligonucleotides, ribozymes EPO906 and siRNA H Accomplished manifold. Researchers have developed beyond transcriptional regulators, means for change the plasma membrane as well as compounds which multiresistant selectively on cancer cells. Antisense oligonucleotides are antisense oligonucleotides, another method for inhibiting the expression of ABC transporters. The mechanisms by which these oligonucleotides function are complex and not yet completely Constantly elucidated Rt. Phosphorothioate oligonucleotides are the first generation of anti-sense molecules. They are resistant to nucleases, but produce k Can pharmacological effects independent-Dependent antisense effects.
A major concern is with respect to these molecules have cellular uptake and researchers demonstrated that maintaining the administration of lipofectin required partial ABCB1 gene silencing. Au Addition Ver changes Resorptionsverst in GAIN than the combination 5 silencer cholesterol improved product without the need for cationic lipids. Concentrations in the micromolar range down are necessary to the protein content in the H Reduce half. Kang et al. Note that chim Hexitol nucleic acid oligonucleotides acids Gapmer are effective in inhibiting gene expression of ABCB1 at nanomolar concentrations. Ribozymes are catalytic RNA ribozymes H Manifold with inh Pensions Spaltungsaktivit t endoribonucleolytic with which a specific mRNA in a particular position, to align a pattern NUX, where N is any nucleotide, and X is a ribozyme, C or U.
The researchers con U targeting ABCB1, ABCG2 and ABCC2. These three ribozymes were then combined in a three multitarget multiribozyme trans effect of ribozymes against hammer ABCB1, ABCG2 and ABCC2 three cis-acting ribozymes ABCB1 and three ABCB1 sequences homologous spacer directed. This autonomous MTMR erf Leads autocatalytic cleavage of the ribozyme per se free cis-active trans-acting ribozymes act on the targeted transcript. This new approach could split the ABC transporter specific transcripts in resistant cell lines. Small RNA interference