pylori-negative controls.

The discriminant function can be calculated easily from serologic data in a cost-effective manner that requires only low staffing. We consider it suitable for enabling mass screening of gastric cancer. Sex, age, gastrin, and PGs were selected as parameters, and various combinations of these were investigated for the discriminant function. Although previous reports indicated that neither age nor sex affected basal gastrin and pepsinogen concentrations in H. pylori-negative subjects [27, 28], discriminant function using sex and age produced better results than when these parameters were not used. When the function for mass screening is used, the sensitivity must be sufficiently high to reduce all false negative results.

The specificity should also be as high as possible. As a result, the function using all parameters, including sex, age, gastrin, and PGs produced the best results. We could click here distinguish patients in group A’ from true H. pylori-negative controls with 85% sensitivity and 84% specificity when the cutoff of the calculated value using the function was set on condition that both the sensitivity and the specificity were over 80% and the sensitivity became as high as possible. Although the number of patients in group A’ was not enough for multivariate logistic regression, this approach showed the high potential of the discriminant function for distinguishing high-risk patients (as well as patients after H. pylori eradication therapy) from true H. pylori-negative VX-770 subjects. However, in this study, true H. pylori-negative

controls were selected from patients who visited Hiroshima University hospital for some treatment and they were not healthy selleck products regional residents. We did not investigate the differences in the clinical characteristics including smoking, alcohol intake, and so on, between group A’ and true H. pylori-negative controls, which would affect the condition of gastric mucosa and serum markers. Therefore, it is necessary to analyze more cases to investigate the utility of the function in the general population. As discussed above, a certain number of high-risk patients in group A could develop gastric epithelial neoplasm. However, many papers have already reported that people in group A rarely develop gastric cancer [11, 12, 24, 25]. Ohata et al. [9] reported that none of 4655 normal male individuals in group A who could be followed-up for at least 10 years had developed gastric cancer. This discrepancy may be because of the age of the subjects. The mean age of people in group A was 48.3 years in Ohata’s study and 69.8 years in our study. Therefore, gastric cancer may appear when patients are followed-up into old age. When young generations undergo unexpected H. pylori eradication, the gastric mucosal atrophy should be relatively mild. Therefore, they may not be at a high risk for gastric cancer development.