This study was supported by GSK Pharmaceuticals Europe, COL 10974

This study was supported by GSK Pharmaceuticals Europe, COL 109743. M. Moroni (Chair), G. Carosi, R. Cauda, F. Chiodo, A. d’Arminio Monforte, G. Di Perri, M. Galli, R. Iardino, G. Ippolito, A. Lazzarin, R. Panebianco, G. Pastore and C. F.

Perno. A. Ammassari, A. Antinori, C. Arici, C. Balotta, P. Bonfanti, M. R. Capobianchi, A. Castagna, F. Ceccherini-Silberstein, A. Cozzi-Lepri, A. d’Arminio Monforte, A. De Luca, C. Gervasoni, E. Girardi, S. Lo Caputo, R. Murri, C. Mussini, M. Puoti and C. Torti. M. Montroni, G. Scalise, M. C. Braschi, A. Riva (Ancona); U. Tirelli, F. Martellotta (Aviano-PN); G. Pastore, N. Ladisa (Bari); F. Suter, C. Arici (Bergamo); F. Chiodo, V. Colangeli, C. Fiorini, O. Coronado (Bologna); G. Carosi, G. Cristini, C. Torti, click here C. Minardi, D. Bertelli (Brescia); T. Quirino (Busto Arsizio); P. E.

Manconi, P. Piano (Cagliari); E. Pizzigallo, M. D’Alessandro (Chieti); F. Ghinelli, L. Sighinolfi (Ferrara); F. Leoncini, F. Mazzotta, M. Pozzi, S. Lo Caputo (Firenze); B. Grisorio, S. Ferrara (Foggia); G. Pagano, G. Cassola, A. Alessandrini, R. Piscopo (Genova); F. Soscia, Selleck ABT 199 L. Tacconi (Latina); A. Orani, P. Perini (Lecco); F. Chiodera, P. Castelli (Macerata); M. Moroni, A. Lazzarin, G. Rizzardini, L. Caggese, A. d’Arminio Monforte, A. Galli, S. Merli, C. Pastecchia, M. C. Moioli (Milano); R. Esposito, C. Mussini (Modena); N. Abrescia, A. Chirianni, M. De Marco, R. Viglietti (Napoli); C. Ferrari, P. Pizzaferri (Parma); G. Filice, R. Bruno (Pavia); G. Magnani, M. A. Ursitti (Reggio Emilia); M. Arlotti, P. Ortolani

(Rimini); R. Cauda, Pyruvate dehydrogenase lipoamide kinase isozyme 1 A. Antinori, G. Antonucci, P. Narciso, V. Vullo, A. De Luca, M. Zaccarelli, R. Acinapura, P. De Longis, M. P. Trotta, M. Lichtner, F. Carletti, (Roma); M. S. Mura, M. Mannazzu (Sassari); P. Caramello, G. Di Perri, G. C. Orofino, M. Sciandra (Torino); E. Raise, F. Ebo (Venezia); G. Pellizzer, D. Buonfrate (Vicenza). “
“To evaluate the use of raltegravir with unboosted atazanavir in combination with one nucleoside reverse transcriptase inhibitor (NRTI) (lamivudine or emtricitabine) as a potentially well-tolerated once-daily (qd) maintenance regimen. We compared the pharmacokinetics of raltegravir 400 mg twice daily (bid) with raltegravir 800 mg qd in HIV-infected patients (n = 17) on unboosted atazanavir (600 mg qd) in combination with lamivudine or emtricitabine. The area under the plasma concentration vs. time curve for a dose interval t (AUC0–t) of 800 mg qd divided by 2 was not significantly different from the AUC0–t of 400 mg bid (P = 0.664) but the minimum concentration (Cmin) was 72% lower with the qd regimen (P = 0.002). The regimen was well tolerated and the viral load remained undetectable in all patients during the 6 weeks of the study follow-up.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>