There was no statistically significant difference in overall succ

There was no statistically significant difference in overall success rates between CH-IPT and 3Mix-MP in treating deep caries approaching the pulp in mandibular primary molars at either 6–11 month or 12–29 month follow-up. Due to the toxicity and potential carcinogenicity of formocresol (FC)[1], indirect pulp treatment (IPT) has been studied as a potential replacement of FC pulotomy[2]. The guidelines of the American Academy of Paediatric Dentistry state that IPT is preferable

to pulpotomy when the pulp is normal or has a diagnosis of reversible pulpitis because IPT has shown success in long-term studies and allows for normal exfoliation[3]. There have been various medicaments used for IPT, ranging from calcium hydroxide[4-6], glass ionomer cement[7, 8], resin-modified glass ionomer cement[9], to dentine bonding agents[4]. The Cariology Research Unit of the Niigata University School of Dentistry has developed a concept of DZNeP in vivo Lesion Sterilization & Tissue Repair (LSTR) using a mixture of antibacterial drugs to disinfect dentinal, pulpal, and periapical lesions. If the lesions were disinfected, tissue repair typically resulted. Metronidazole was first chosen because of its wide bactericidal spectrum against anaerobes. Some bacteria in the lesions were resistant to metronidazole, however. Two other antibacterial drugs, ciprofloxacin and minocycline, were mixed with metronidazole to generate the so-called 3Mix

preparation[10]. In vitro, Talazoparib manufacturer in vivo, and in situ studies have shown 3Mix antibiotics to be effective against oral bacteria[11-15], including when used for endodontic lesions of primary teeth[10, 15]. Using a mixture of metronidazole, ciprofloxacin, and minocycline with macrogol and propylene glycol (3Mix-MP) resulted in clinical and radiographic success in treating

infected root canals in Metalloexopeptidase primary teeth[16-18]. Using stricter criteria, Trairatvorakul & Detsomboonrat found a contrary result in a 2- year follow-up study of non-instrumentation endodontic treatment using 3Mix-MP, which showed a good clinical success rate, but a low radiographic success rate, however. The study concluded that 3Mix-MP treatment could not replace conventional root canal treatment agents as a long-term therapy[19]. Although the procedure of using 3Mix-MP to disinfect dentinal lesions and IPT techniques are similarly non-invasive, there have been no randomized controlled trials to compare the clinical and radiographic success rate of 3Mix-MP with that of CH- IPT for deep caries approaching the pulp in primary molars. The purpose of this study was to compare the clinical and radiographic success rates of CH-IPT and 3Mix-MP in deep carious lesions approaching the pulp in mandibular primary molars. Patients aged 3–8 years old, in the outpatient Paediatric Dentistry department, Chulalongkorn University or students at schools near Chulalongkorn University, were recruited for this study.

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