In the western countries, it is extremely rare, and in the developing countries (TB-endemic countries), there are rare reports analyzing the clinical features and outcomes of anal TB. Methods: During a period of nine years (January 2004 to December 2012), among 11,609 patients who underwent perianal surgery for fistula, 80 patients were diagnosed with anal TB, based on at least one of the following criteria: 1) AFB (+) from biopsies; 2) typical caseating granulomatous necrosis; 3) PCR (+) for M. tuberculosis, or 4) histological demonstration
of granuloma in patients who rapidly responded to anti-TB medication. Demographic features, clinical symptom, type of fistula, anti-TB medication, selleck inhibitor histopathology, radiologic and colonoscopic features were analyzed. Results: Anal TB was more common in males (M : F = 64:16). The overall incidence rates of anal TB diagnosed after fistula surgeries were 0.7%. The median age was 37.5 (22 to 66).52 of 80 (65%) patients had coexistent pulmonary TB (11 active and 41 inactive TB). 6 of 20 (30%) patients had TB colitis. The most common type of anal fistula was intersphincteric type (51%). 45 of 80 (56%) patients revealed positive AFB http://www.selleckchem.com/products/Maraviroc.html stain. All patients who completed anti-TB treatment for at least 6 months after surgery were cured without recurrence except for
one patient. Conclusion: When patients presenting with prolonged or recurrent perianal 上海皓元医药股份有限公司 abscess or fistula were encountered, we should still keep in mind for the possibility of anal TB as well as Crohn’s disease. Key Word(s): 1. clinical features; 2. outcomes; 3. tuberculous; 4. anal fistula; Presenting Author: ZHENGSHUANG YING Corresponding Author: ZHENGSHUANG YING Affiliations: Department of Digestive Medicine, RenMin Hospital of WuHan University Objective: Post – inflammatory irritable bowel syndrome (PI – IBS) is a commonly disease, however which pathogenesis is still unclear. Abdominal distension, diarrhea and intestinal motility disfunction mainly clinical manifestations. The interstitial cells of Cajal (ICCs) is the gastrointestinal pacemaker
cells of gastrointestinal tract, which could play key role in the processing ofproducing and maintaining the slow wave current. Calcium activated chloride channels (CaCCs) participated in the platform of pacemaker current potential of ICC, therefore, the calcium activated chloride channels have an important role in regulating on gastrointestinal dynamic activity. TMEM16A is an important structural component of CaCCs, which could affect the ICCs pacemaker by regulating the CaCCs activities, and then ultimately affect the entire gastrointestinal motivation activities. The purpose of this article is to explore the effect of TMEM16A in the development of PI-IBS through making the PI-IBS rats model, and then detecting the expression of inflammatory factors IL-4 and expression changes of TMEM16A.